This comedy drama is about the adventures of two drag queens, Mitzi and Felicia, and a transsexual, Bernadette who hit the road in a bus called Priscilla. They make their way across the Australian desert to perform in a cabaret show in Alice Springs. During the course of the journey they paint their bus lavender, dance in the desert in flamboyant costumes and encounter some Aboriginals and a group of prejudiced miners. The music consists mostly of seventies disco hits.